Title:
Research prospect of cortistatin and its expression regulation
- 文章编号:
- 1671-8259(2011)02-0137-04
- 作者:
- 王振原; 杨海燕
- 西安交通大学医学院病理学系， 陕西西安 710061
- Author(s):
- WANG Zhen-yuan; YANG Hai-yan
- Department of Pathology, Medical School of Xi’an Jiaotong University, Xi’an 710061, China
- 关键词:
- ; 皮质抑素; 中枢神经系统; 脑肿瘤; 神经肽
- Keywords:
- ; cortistatin; central nervous system; brain tumor; neuropeptide
- 分类号:
- R739.41
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 摘要：皮质抑素来源于生长抑素/尾加压素家族的神经肽类，于1996年被发现，在人体中枢神经系统、内分泌系统和免疫系统中广泛分布。人体和动物实验表明，皮质抑素能与生长抑素受体、生长素受体、MrgX2受体结合，参与多种生理、生化及病理过程，如调节学习和记忆、诱导慢波睡眠、保护缺血损伤的神经、参与炎症过程、抑制血管内皮细胞增殖及迁移、减轻血管钙化，并且在部分肿瘤组织异常表达等。但是，其特异性的受体和信号通路以及确切的生理作用机制并未完全阐明。目前，部分研究热点逐渐集中于皮质抑素在人中枢神经系统肿瘤中的表达与调控，期望在脑肿瘤的发病机制及临床诊治领域获得新的进展。
- Abstract:
- ABSTRACT: Discovered in 1996, cortistatin (CST) is a neuropeptide from the somatostatin (SRIF)/urotensin (UII) family. It is widely distributed in the central nervous system, endocrine system and immune system. Experiments on humans and animals show that CST can bind with somatastin receptor, growth hormone receptor and MAS-related gene X2 (MrgX2) receptor. CST is also involved in various physiological, biochemical and pathological processes, such as regulating learning and memory, inducing slow-wave sleep, protecting nerves with ischemic injury, participating in inflammation, inhibiting vascular endothelial cell proliferation and immigration, lessening angiosteosis, and being expressed abnormally in some tumors. However, its specific receptor and signal pathway as well as the mechanism of the exact physiological action remain unclear till now. Currently, some research has gradually focused on CST’s expression and regulation in tumors of human central nervous system in the hope of making new findings of the pathogenesis of brain tumor as well as its clinical diagnosis and treatment.
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