| 王晓虹1，王文锋2，马爱群3，曹永孝4 ACE、ACE2、AngⅡ在甲状腺毒症大鼠心血管损害中的作用 |
| 论文编辑部-新丝路理论网 2011-03-31 15:16:11 作者:中华医学之家：http://www.xinxi85.com 来源: 文字大小:[大][中][小] |
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Title:
The role of ACE, ACE2 and AngⅡ in cardiovascular lesion of thyrotoxicosis rats
- 文章编号:
- 1671-8259(2011)02-0141-04
- 作者:
- 王晓虹1; 王文锋2; 马爱群3; 曹永孝4
- 西安交通大学医学院：1. 第一附属医院干二病区；2. 2008级硕士研究生；3. 第一附属医院心内科；4. 药理学系，陕西西安 710061
- Author(s):
- WANG Xiao-hong1; WANG Wen-feng2; MA Ai-qun3; CAO Yong-xiao4
- Medical School of Xi’an Jiaotong University: 1. the Second Ward of Carders, the First Affiliated Hospital; 2. Class 2008 of Master’s Degree Program;
3. Department of Cardiology, the First Affiliated Hospital; 4. Department of Pharmacology, Xi’an 710061, China
- 关键词:
- ; 血管紧张素转换酶2; 血管紧张素Ⅱ; 甲状腺毒症; 心肌重构
- Keywords:
- angiotensin-converting enzyme 2 (ACE2); angiotensin Ⅱ(AngⅡ); thyrotoxicosis; myocardial remodeling
- 分类号:
- R581
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 摘要：目的 检测甲状腺毒症大鼠心肌及血清中血管紧张素转换酶(ACE)、血管紧张素转换酶2(ACE2)、血管紧张素Ⅱ(AngⅡ)含量的变化，探讨其在甲状腺毒症心血管损害中的作用。方法 45只成年雄性SD大鼠随机分为4组：①空白对照组，给予盐水5mL/kg灌胃；②氯沙坦组，氯沙坦20mg/kg灌胃；③甲状腺毒症模型组，左旋甲状腺素钠0.5mg/kg灌胃；④氯沙坦干预的甲状腺毒症组，左旋甲状腺素0.5mg/kg＋氯沙坦20mg/kg灌胃。每日1次，持续4周后处死大鼠，测定心肌与血清ACE、ACE2、AngⅡ含量，病理检查评估甲状腺毒症的损害。结果 甲状腺毒症模型组及氯沙坦干预的甲状腺毒症组血清及心肌ACE2、心/体重比(H/B)较空白对照组显著增加，但氯沙坦干预的甲状腺毒症组H/B小于甲状腺毒症模型组；甲状腺毒症模型组血清ACE较空白对照及氯沙坦组显著性增加，而心肌ACE、AngⅡ及血清AngⅡ在各组间的差别无统计学意义。结论 在过多甲状腺素的刺激下，各种分子机制启动引起的心肌重构并可被氯沙坦逆转；ACE2升高可以促进甲状腺毒症大鼠心肌重构的发生。
- Abstract:
- ABSTRACT: Objective To detect the changes of angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2) and angiotensin Ⅱ (AngⅡ) contents in the serum and myocardium so as to explore their role in cardiovascular lesion of thyrotoxicosis rats. Methods Totally 45 male adult Sprague-Dawley (SD) rats were randomized into 4 groups and administered intragastrically once a day: blank control group with physiological saline (5mL/kg ), losartan group with losartan (20mg/kg), thyrotoxicosis model group with levothyroxine (0.5mg/kg), and losartan-treatment thyrotoxicosis group with levothyroxine (0.5mg/kg) plus losartan (20mg/kg). After 4-week treatment, the rats were killed to test ACE, ACE2 and AngⅡ contents in the serum and myocardium and assess the pathological changes of thyrotoxicosis. Results The thyrotoxicosis model group and losartan-treatment thyrotoxicosis group had a significantly higher serum ACE2, myocardial ACE2 and heart weight-to-body weight ratio (H/B) than blank control group, but H/B was smaller in losartan-treatment thyrotoxicosis group than in thyrotoxicosis model group. The serum ACE increased in thyrotoxicosis model group compared with that in blank control group, while the myocardial ACE, myocardial AngⅡ and serum AngⅡ did not significantly differ among the groups. Conclusion Stimulated by excessive thyroid hormone, myocardial remodeling occurs via activating various molecular mechanisms, and that can be reversed by losartan. The increase of ACE2 can promote myocardial remodeling in thyrotoxicosis rats.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2010-06-10 修回日期：2010-09-29
作者简介：王晓虹(1963-)，女(汉族)，副教授. 研究方向：心血管疾病的基础与临床研究. E-mail: 291406264@QQ.com
中华医学之家：http://www.xinxi85.com
投稿信箱：zhyxzj85@163.com
联系电话：029--85327298 主编QQ：693891972 |
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