临床肺科杂志 , Journal of Clinical Pulmonary Medicine, 编辑部邮箱 , 2011年11期 【作者】 张建辉; 陶一江; 陈晓笑; 马航; 陈金亮;
【Author】 ZHANG Jian-hui,TAO Yi-jiang,CHEN Xiao-xiao,MA Hang,CHEN Jin-liang(The Second Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu)
【机构】 南通大学第二附属医院呼吸科(南通市第一人民医院);
【摘要】 目的了解哮喘患者呼出气冷凝液(EBC)中TNF-α、8-isoPG的含量,并观察激素治疗对其水平的影响。方法选择轻、中度哮喘患者38例和健康对照组25例,其中轻度哮喘组20例、中度哮喘组18例。轻度哮喘组予以吸入激素治疗一个月。采用ELISA双抗体夹心法测定EBC中TNF-α、8-isoPG的含量。结果哮喘组EBC中TNF-α、8-isoPG的含量显著高于对照组(P<0.05)。结论哮喘患者EBC中TNF-α、8-isoPG的含量增高与哮喘严重程度有关,可作为检测哮喘气道炎症反应和氧化应激的客观指标。吸入糖皮质激素治疗后TNF-α、8-isoPG含量无显著变化,提示糖皮质激素不能完全有效控制哮喘患者气道炎症反应和氧化应激损伤。 更多还原
【Abstract】 Objective To examine the levels of TNF-α and 8-isoPG in exhaled breath condensates(EBC) in patients with asthma,and to investigate the effect of corticosteroid treatment.Methods 38 patients with mild to moderate asthma and 25 nomal controls were included in the study.Among 38 patients,20 cases were mild asthma group and 18 cases were moderate asthma group.The mild asthma group were treated by Corticosteroid for one month.TNF-α and 8-isoPG in EBC were assayed by enzyme linked immunosorbent assay.... 更多还原 【关键词】 哮喘; 呼出气冷凝液; 糖皮质激素; 肿瘤因子α; 8-异前列腺素; 【Key words】 asthma; exhaled breath condensates; corticosteroid; tumor necrosis factor-α; 8-isoprostane; 【分类号】R562.25
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