【作者】 王炘; 詹志刚; 郑林; 涂铭;
【Author】 WANG Xin,ZHAN Zhi-gang,ZHENG Lin,TU Min Department of Gastroenterology,the 92 Hospital of PLA,Nanping,353000,China.
【机构】 中国人民解放军第九二医院消化内科;
【摘要】 目的探讨胃食管反流病(GERD)患者夜间酸突破(NAB)与食管酸暴露的关系。方法将45例GERD患者随机分为两组,对照组(21例)给予雷贝拉唑钠10 mg早晚各1次口服,试验组(24例)治疗同对照组外晚间睡前另加服雷尼替丁150 mg,疗程共7 d。两组治疗前后行24 h食管、胃pH监测,及反流诊断问卷评分(RDQ),并进行比较。结果加服雷尼替丁组夜间酸突破的发生率为20.83%,单用雷贝拉唑钠组为57.14%,两组比较差异有统计学意义(P<O.05);两组治疗前后的夜间食管pH<4的中位时间百分比及RDQ评分差异无统计学意义(P>0.05)。结论食管酸暴露和食管反流症状的控制不依赖于夜间酸突破的缓解,更大程度上取决于食管动力异常的改善。 更多还原
【Abstract】 Objective To discuss the relationship between nocturnal acid breakthrough(NAB)and esophageal acid exposure in patients with gastroesophageal reflux disease(GERD).Methods 45 cases of GERD patients were divided into two groups at random,including experimental group(24 cases) and control group(21 cases).Both of the two groups were given sodium rabeprazole 10 mg in the morning and the evening respectively,and experimental group(24 cases) was also given ranitidine 150 mg at bedtime,7 days as a course... 更多还原 【关键词】 胃食管反流病; 夜间酸突破; 食管酸暴露; 雷贝拉唑钠; 雷尼替丁; 【Key words】 Gastroesophageal reflux disease(GERD); Nocturnal acid breakthrough(NAB); Eesophageal acid exposure; Sodium rabeprazole; Ranitidine; 【基金】 全军医药卫生科研基金课题,课题编号07M061 【分类号】R571
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