魏源源1(综述)/刘　燕1,/刘东银2/代瑞华1/刘　翔1(审校)

(1. 复旦大学环境科学与工程系，上海 200433； 2. 大庆师范学院， 黑龙江 大庆  163712)

　　【摘要】受海水入侵影响严重的沿海地区，其饮用水源中常含有较高浓度的碘离子。研究表明，当原水中含有碘离子时，经氯、臭氧、氯胺或二氧化氯消毒后均会产生碘代消毒副产物，其副产物具有更高的细胞毒性和遗传毒性。因此，对碘代副产物的研究更具实际意义，而目前国内对于消毒形成的碘代副产物的研究还未见报道，本文针对碘代副产物的健康风险，从其产生的原因、机制、影响因素及细胞毒性和遗传毒性等方面对国外学者的相关研究成果进行了综述。

　　【关键词】 饮用水消毒； 碘代消毒副产物； 健康风险

　　中图分类号： R123　　　　文献标识码： A　　　　文章编号： 1004－616X(2010)05－0404－05

参考文献

[1] Richardson SD, Plewa MJ, Wagner ED, et al. Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by_products in drinking water: A review and roadmap for research [J]. Mutation Research, 2007, 636(1/2/3):178－242.

[2]  Krasner SW, McGuire MJ, Jacangelo JG, et al. The occurrence of disinfection byproducts in U.S. drinking water[J]. J Am Water Works Assocation, 1989, 81(8):41－53.

[3]  Kurokawa Y, Aoki S, Matsushima Y, et al. Dose－response studies on the carcinogenicity of potassium bromate in F344 rats after long_term oral administration [J]. J Natl Cancer Inst,  1986, 77(4): 977－982.

[4]  U.S. Environmental Protection Agency, IRIS_Integrated Risk Information System(CP/OL). http://www.epa.gov/iriswebp/iris/index.html.

[5] Cemeli E, Wagner ED, Anderson D, et al. Modulation of the cytotoxicity and genotoxicity of the drinking water disinfection byproduct iodoacetic acid by suppressors of oxidative stress[J]. Environ Sci Technol, 2006, 40(6):1878－1883.

[6] Stuart WK, Howard SW, Susan DR, et al. Occurrence of a new generation of disinfection byproducts [J]. Environ Sci Technol, 2006, 40(23):7175－7185.

[7]  Glaze WE, Henderson JE, Smith G. Analysis of new chlorinated organic compounds formed by chlorination of municipal wastewater[M]. //RJ Jolley. Water Chlorination: Environmental Impact and Health Effects. Ann Arbor, MI: Ann Arbor Science, 1975： 139－159.

[8]  Plewa MJ, Muellner MG, Richardson SD, et al. Occurrence, synthesis and mammalian cell water disinfection byproducts [J]. Environ Sci Technol, 2008,42(3)：955－961.

[9] Richardson SD, Fasano F, Ellington JJ, et al. Occurrence and mammalian cell toxicity of iodinated disinfection byproducts in drinking water [J]. Environ Sci Technol, 2008,42(22)： 8330－8338.

[10] Hansson RC, Henderson MJ, Jack R, et al. Iodoform taste complaints in chloramination [J]. Water Res, 1987, 21(10):1265－1271.

[11] Karpel Vel Leitner N, Vessella J, Dore′ M, et al. Chlorination and formation of organoiodinated compounds: the important role of ammonia [J].Environ Sci Technol, 1998, 32(11):1680－1685.

[12] Fuge R, Johnson CC. The geochemistry of iodine_ a review [J]. Environ Geochem Health, 1986,8(2):31－54.

[13] Collins AG, Egleson GC. Iodine abundance in oilfield brines in Oklahoma [J]. Science, 1967, 156(3777):934－935.

[14] Von Gunten U. Ozonation of drinkingwater: Part II. Disinfection and by_product formation in presence of bromide, iodide or chlorine [J]. Water Res, 2003, 37(7):1469－1487.

[15] Hua G, Reckhow DA, Kim J. Effect of bromide and iodide ions on the formation and speciation of disinfection byproducts during chlorination [J]. Environ Sci Technol, 2006,40(9): 3050－3056.

[16] Thomas RF, Weisner MJ, Brass HJ. The fifth trihalomethane: dichloroiodomethane, its stability and occurrences in chlorinated drinking water. In: Water Chlorination: Environmental Impact and Health Effects[M]. Ann Arbor Science, Ann Arbor, MI, 1980: 161－168.

[17] Cancho B, Ventura M, Galceran M, et al. Determination, synthesis and survey of iodinated trihalomethanes in water treatment processes [J]. Water Res, 2000, 34(13):3380－3390.

[18] Bichsel Y, von Gunten U. Formation of iodo_trihalomethanes during disinfection and oxidation of iodide_containing waters [J]. Environ Sci Technol, 2000, 34(13):2784－2791.

[19] Brass HJ, Feige MA, Halloran T, et al. The national organic monitoring survey: samplings and analyses for purgeable organic compounds[M]. //RB Pojasek. Drinking water quality enhancement through source protection. Michigan: Ann Arbor Science Publishers, Michigan, 1977:398.

[20] Richardson SD. Disinfection by_products and other emerging contaminants in drinking water [J]. Trends Anal Chem, 2003,22(10):666－684.

[21] Woo YT, Lai D, McLain JL, et al. Use of mechanism_based structure－activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by_products [J]. Environ Health Perspect, 2002,110 (Sup 1):75－87.

[22] Roldán_Arjona T, Pueyo C. Mutagenic and lethal effects of halogenated methanes in the Ara test of Salmonella typhimurium: quantitative relationship with chemical reactivity [J]. Mutat Res 1993,8(2):127－131.

[23] Hikiba H, Watanabe E, Barrett J C, et al. Ability of fourteen chemical agents used in dental practice to induce chromosome aberrations in Syrian hamster embryo cells [J]. J Pharmacol Sci, 2005,97(1):146－152.

[24] Plewa MJ, Wagner ED, Richardson SD, et al. Chemical and biological characterization of newly discovered iodoacid drinking water disinfection byproducts [J]. Environ Sci Technol, 2004,38(18):4713－4722.

[25] Hunter ES III, Tugman JA. Inhibitors of glycolytic metabolism affect neurulation_staged mouse conceptuses in vitro [J]. Teratology, 1995,52(6):317－323.

[26] World Health Organization. Guidelines for Drinking_Water Quality, second addendum to third edition[M]. Geneva: WHO,2008:43－66.

[27] Taurog A, Howells EM, Nachimson HI. Conversion of iodate to iodide in vivo and in vitro [J]. J Biol Chem, 1966, 241(20):4686－4693.

[28] World Health Organization. Guidelines for drinking water quality[G/OL]. http://www.who.int/water_sanitation_health/dwq/gdwq3rev/en.

[29] Muellner MG, Wagner ED, McCalla K, et al. Haloacetonitriles vs. regulated haloacetic acids: are nitrogen containing DBPs more toxic? [J]. Environ Sci Technol, 2007, 41(2): 645－651.

[30] Bichsel Y, von Gunten U. Oxidation of iodide and hypoiodous acid in the disinfection of natural waters [J]. Environ Sci Technol, 1999, 33(22):4040－4045.

[31] Garland JA, Elzerman AW, Penkett SAJ. The mechanism for dry deposition of ozone to seawater surfaces [J]. Geophys Res, 1980, 85(C12):7488－7492.

[32] Nagy JC, Kumar K, Margerum DW. Non_metal redox kinetics _ oxidation of iodide by hypochlorous acid and by nitrogen trichloride measured by the pulsed_accelerated_flow method [J]. Inorg Chem, 1988, 27(16):2773－2780.

[33] Kumar K, Day RA, Margerum DW. Atom_transfer redox kinetics － general_acid_assisted oxidation of iodide by chloramines and hypochlorite [J]. Inorg Chem, 1986,25(24):4344－4350.

[34] Fabian I, Gordon G. The kinetics and mechanism of the chlorine dioxide_iodide ion reaction [J]. Inorg Chem,1997,36(12):2494－2497.

[35] Bichsel Y, von Gunten U. Hypoiodous acid: kinetics of the buffer_catalyzed disproportionation [J]. Water Res,2000,34(12):3197－3203.

[36] Hong HC, Reckhow DA. Comparison of disinfection byproduct forma_ tion from chlorine and alternative disinfectants [J]. Water Res, 2007, 41(18):1667－1678.

[37] Gittelman TS, Yohe TL. Treatment of the iodinated haloform medicinal odors in drinking water[M]. //Denver, CO. AWWA Water Quality Technology Conference, 1989:105－123.

[38] Hong HC, Reckhow DA. Characterization of disinfection byproduct precursors based on hydrophobicity and molecular size [J]. Environ Sci Technol, 2007,41(9):3309－3315.

[39] Gallard H, Allard S, Nicolau R, et al. Formation of iodinated organic compounds by oxidation of iodide_containing waters with manganese dioxide [J]. Environ Sci Technol,2009,43(18):7003－7009.

收稿日期： 2009－10－30； 修订日期： 2009－11－30

基金项目： 国家高技术研究发展计划(863计划)重点项目(2008AA062501)

作者简介： 魏源源(1981－　)，女，博士研究生，研究方向：污染控制。