临床肺科杂志 , Journal of Clinical Pulmonary Medicine, 编辑部邮箱 , 2011年11期 【作者】 陈嘉宝; 刘俊华; 刘益飞; 薛小飞;
【Author】 CHEN Jia-bao,LIU Jun-hua,LIU Yi-fei,XUE Xiao-fei(Department of Thoracic Surgery,Affiliated Hospital of Nantong University,Nantong 226001,China)
【机构】 南通大学附属医院心胸外科; 南通大学附属医院病理科;
【摘要】 目的研究Atoh1(Atonalhomolog1)基因在肺癌中的表达。方法用实时荧光定量RT-PCR技术检测肺癌组织与癌旁组织中Atoh1的表达,采用表达的相对量进行结果分析。结果与癌旁组织相比,Atoh1 mRNA在肺癌组织中表达显著下调(P<0.05),两者比值约为0.46/1。结论 Atoh1基因在肺癌组织中的表达下调,可能与肺癌的发生、发展有关,可能成为诊断和治疗的新靶点。 更多还原
【Abstract】 Objective To investigate the Atoh1 expression in lung cancer.Methods Atoh1 mRNA expression levels in lung cancer tissues were tested by reverse transcription polymerase chain reaction(RT-PCR).2-△△CT) method was used for analyzing the difference on Atoh1 expression.Result The levels of Atoh1 mRNA were down-regulated in lung cancer.Conclusion The down-regulation of Atoh1 expression may correlate with lung cancer.Atoh1 gene may serve as a new target for lung cancer diagnosis and treatment. 更多还原 【关键词】 Atoh1基因; 肺癌; 基因表达; 【Key words】 Atoh1 gene; Lung cancer; Gene expression; 【分类号】R734.2
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