【作者】 徐常钦; 马灵军;
【Author】 XU Chang-qin,MA Ling-jun Department of Ophthalmology,China-Japan Union Hospital,Jilin University,Changchun 130033,China
【机构】 吉林大学中日联谊医院眼科;
【摘要】 目的系统评价单用激光光凝(Laser)与激光光凝联合玻璃体腔注射曲安奈德(Laser+IVTA)治疗糖尿病性黄斑水肿的疗效与安全性。方法计算机检索Cochrane Library、PubMed、EMbase、CNKI、VIP、WanFangData,检索时间均从建库至2011年9月,并追索纳入文献的参考文献。纳入单用Laser与Laser+IVTA比较治疗糖尿病性黄斑水肿的随机对照试验(RCT),由两位评价员按照纳入排除标准独立进行资料提取、质量评价并交叉核对后,采用RevMan 5.0软件进行Meta分析。结果纳入10个RCT,共525只患眼,方法学质量评级均为B级。Meta分析结果显示:随访结束时,Laser+IVTA与单用Laser比较,在最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)方面,两组差异均有统计学意义[RR=–0.14,95%CI(–0.20,–0.08);RR=–56.78,95%CI(–84.03,–29.54),P均<0.000 1];Laser+IVTA组发生眼压升高需治疗和白内障进展需手术治疗的人数明显高于单用Laser组,但两组在发生玻璃体积血、... 更多还原
【Abstract】 Objective To evaluate the single-use of laser photocoagulation(LP) and the combined-use of laser photocoagulation plus intravitreal triamcinolone(LP+IVTA) for diabetic macular edema(DME) in terms of clinical therapeutic effect and safety.Methods Such databases as The Cochrane Library,Medline,Embase,CBM,CNKI and Wanfang Data were searched from the date of their establishment to September 2011,and the references of all included studies were also traced,so as to identify the randomized controlled t... 更多还原 【关键词】 激光光凝; 曲安奈德; 玻璃体腔注射; 糖尿病性黄斑水肿; 系统评价; Meta分析; 随机对照试验; 【Key words】 Laser photocoagulation; Intravitreal triamcinolone; Intravitreous injection; Diabetic macular edema; Systematic review; Meta-analysis; Randomized controlled trial;
【分类号】R774.5
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