【作者】 秦静; 宋菲; 马莉; 张蓓; 甄玲玲; 张彤哲;
【Author】 QIN Jing,SONG Fei,MA Li,ZHANG Bei,ZHEN Ling-ling,ZHANG Tong-zhe Department of Emergency Intensive Care Unit,the Second Hospital of Lanzhou University,Lanzhou 730000,China
【机构】 兰州大学第二医院急诊ICU;
【摘要】 目的评价国产伊布利特与普罗帕酮对治疗心房颤动和扑动的有效性及安全性。方法计算机检索CBM(1978~2011.10)、VIP(1989~2011.10)、CNKI(1994~2011.10)和WanFang Data(1998~2011.10),查找所有有关国产伊布利特与普罗帕酮治疗心房颤动和扑动的临床随机对照试验(RCT)。对符合纳入标准的RCT,由两位评价员按Cochrane系统评价的方法,独立进行资料提取、质量评价并交叉核对后,采用RevMan 5.0软件对数据进行Meta分析。结果最终纳入16个研究,1 196例患者。Meta分析结果显示:与普罗帕酮相比,①在疗效方面:国产伊布利特90 min内、4 h及24 h内房颤、房扑总体转复率更高[OR分别为3.32、2.69、3.08,P均<0.0001],亚组分析结果显示90 min内房颤转复率及90 min内房扑转复率也更高,且差异有统计学意义;转复时间方面更短[MD=–25.12,95%CI(–30.43,–19.82),P<0.000 01];②在安全性方面,两者致心律失常发生率差异有统计学意义[OR=3.15,9... 更多还原
【Abstract】 Objective To assess the effectiveness and safety of ibutilide and propafenone in the treatment of atrial fibrillation(AF) and atrial flutter(AFL).Methods All randomized controlled trials(RCTs) on ibutilide and propafenone for AF and AFL were retrieved from databases including CBM(1978 to October 2011),VIP(1989 to October 2011),CNKI(1994 to October 2011) and WanFang Data(1998 to October 2011).The quality of included RCTs was assessed according to the Cochrane Handbook for Systematic Reviews of In... 更多还原 【关键词】 伊布利特; 普罗帕酮; 心房纤颤; 心房扑动; 系统评价; Meta分析; 随机对照试验; 【Key words】 Ibutilide; Propafenone; Atrial fibrillation; Atrial flutter; Systematic review; Meta-analysis; Randomized controlled trial;
【分类号】R541.7
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