【摘要】 内脂素/前B细胞克隆增强因子(visfatin/PBEF)作为新发现的脂肪因子,主要在内脏脂肪和大网膜中表达,具有类胰岛素作用、参与炎症反应和免疫调节等功能。妊娠期妇女处于特殊的生理状态,能量代谢发生特征性改变。最新观点认为妊娠合并症,如妊娠期糖尿病和妊娠期高血压疾病均存在胰岛素抵抗,是妊娠妇女体内代谢功能紊乱所致。近年对visfatin/PBEF的结构和功能、其与代谢综合征、子痫前期、妊娠期糖尿病和胎儿生长受限关系的研究提示,visfatin/PBEF可能参与妊娠相关疾病的发生和发展。就近年关于vis-fatin/PBEF和妊娠合并症的相关研究综述。 更多还原

【Abstract】 Visfatin/pre-B-cell colony-enhancing factor(PBEF) has recently been identified as a novel adipokine with insulin-mimetic effects and a regulatory factor in pro-inflammatory and immunomodulating processes.Visfatin is mainly expressed in adipose tissue,with particularly high level in both visceral and omental adipose tissue.Some clinical associated studies confirmed the association of visfatin and GDM,pre-eclampsia,metabolic syndrome,intrauterine growth restriction.Similarly,the relationship of vi... 更多还原