【摘要】 肝癌缺失基因(deleted in liver cancer genes,DLCs)家族存在于人体多种组织中,其表达产物为RhoGTP酶活化蛋白。该基因家族在多种肿瘤中低表达或不表达,主要通过负性调控Rho蛋白(RhoA,Cdc42)和黏着斑蛋白及两者下游效应因子的活性,抑制细胞骨架形成、黏着斑重组,在肿瘤细胞生长、增殖、侵袭和转移过程中发挥重要作用。雌、孕激素和胰岛素可通过转录后修饰途径调控DLCs蛋白活性,在此类激素相关肿瘤的发生发展中发挥作用。 更多还原

【Abstract】 Deleted in liver cancer genes(DLCs) family is found in several human tissues,and expresses Rho GTPase activation proteins(RhoGAP).Recent studies have suggested that DLCs were underexpressed or absent in various types of human cancers.DLCs negatively regulated Rho proteins,focal adhension proteins and their downstream effectors to restraint cellular cytoskeletal formation and focal adhesion reorganization and played important roles in tomorigenesis,cell proliferation,invasion and migration,DLCs p... 更多还原