【摘要】 目的:通过研究哌甲酯(MPH)及托莫西汀(ATX)治疗前后注意缺陷多动障碍(ADHD)儿童下丘脑-垂体-肾上腺(HPA)轴的功能状态,探讨HPA轴在ADHD中的作用。方法:采用前瞻、双盲、随机对照研究方法,根据美国《精神病诊断与统计手册》(第4版)(DSM-IV)ADHD诊断和分型标准确诊111例6~14岁ADHD男童,其中注意缺陷为主型(ADHD-I)33例,多动-冲动为主型(ADHD-HI)30例,混合型(ADHD-C)48例,对照组为年龄匹配健康男童35名。31例ADHD儿童随机给予MPH治疗和ATX治疗,于治疗前和治疗后1个月进行皮质醇测定。血浆皮质醇测定采用全自动微粒酶免疫分析法,于上午8:00空腹抽血测定。结果:ADHD各组血浆皮质醇水平[(236.12±109.77)nmol/L)均较对照组[(353.32±112.75)nmol/L)明显降低(P<0.01)。ADHD-HI组[(177.62±62.99)nmol/L)]下降程度较ADHD-I组[(246.71±129.27)nmol/L,P<0.05]及ADHD-C组[(265.41±106.00)nmol... 更多还原

【Abstract】 Objective:To explore the relationship between hypothalamus-pituitary-adrenal(HPA) and ADHD.The function of HPA axis in children with ADHD has been investigated before and after the treatment of methylphenidate(MPH) and atomoxetine(ATX).Methods: The clinical study was a prospective,double-blind,randomized case-control trail.One hundred and eleven male children with ADHD between the ages of 6 to 14 years old were included in this study.The diagnosis of ADHD and its three subtypes were according to... 更多还原