【作者】 刘义红; 熊丽萍; 甘斌;
【Author】 Liu Yihong,Xiong Liping,Gan Bin(Xiaogan Hospital Affitiated to Tongji Medical College of Huazhong University of Science and Technology;Xiaogan Central Hospital of Hubei Province,Hubei Xiaogan 432000,China)
【机构】 华中科技大学同济医学院附属孝感医院; 孝感市中心医院;
【摘要】 目的:探讨血清神经肽Y(NPY)和降钙素基因相关肽(CGRP)在新生儿缺氧缺血性脑病(HIE)中的变化及其意义。方法:2008年1月~2009年12月本院新生儿科收治的32例HIE患儿,10例正常足月新生儿,在生后24 h、第3 d、第7 d取血,进行血清NPY和CGRP检测。结果:生后24 h内HIE组血清NPY质量浓度显著高于对照组(P<0.01),且随着病情加重,NPY质量浓度越高;中、重度HIE组NPY质量浓度明显高于轻度HIE组(P<0.01)。NPY浓度以生后24 h内最高,第3 d开始下降,第7 d左右下降最为明显,但仍高于正常对照组。在24 h、3 d、7 d三个时间点,经方差分析显示三组HIE相互之间比较差异有统计学意义(P<0.01)。HIE患儿CGRP随着病情加重而相应升高。轻、中、重度HIE患儿血清CGRP与对照组比较差异有统计学意义(P<0.01),其水平以生后24 h升高最为明显。结论:血清NPY与CGRP可作为判断HIE脑损伤程度、病情发展、判断预后的较为客观的指标,特别是动态测定血清NPY对HIE具有更重要的早期诊断和判断预后的临... 更多还原
【Abstract】 Objective:To study the significance and changes of serum neuropeptide Y(NPY) and calcitonin gene related peptide(CGRP) in neonates with hypoxic-ischemic encephalopathy(HIE).Methods: There were 32 cases of HIE neonates and 10 cases of normal full-term newborn infants in our hospital from January 2008 to December 2009.They were phlebotomized at 24 hours,3 days,7 days after birth and the serum NPY and CGRP were measured.Results: The levels of serum NPY in HIE group were significantly higher than th... 更多还原
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